Diyala Journal for Pure Science DJPS

P- ISSN:2222-8373, E-ISSN:2518-9255

Volume 13, Issue 3, Part 1 , July. 2017

Synthesis and Antibacterial Evaluation of 2-(chloro / ethyl thio / seleno)-1,8-naphthyridine-3-azetidine Derivatives

Mohanad Y.Saleh

Year: 2017, Volume: 13, Issue: 3, Part: 1

Pages: 104-115, DOI: http://dx.doi.org/10.24237/djps.1303.217A 

Language: English

Download :  

Abstract    

Synthesis of new heterocyclic fuse compounds by reaction of N-acetyl-2-amino pyridine with  through Vilsmeier-Haack cyclization to give 2-chloro-3-formyl-1,8-naphthyridine (1) , chloro atom changing with selenium (2) or Et-S- group (3) , the formyl group in the compounds (1,2,3) converted to schiff base by react with aryl amine (4-9), shiff base derivatives  reaction with chloroacetylchloride in triethylamine to give azetidine ring (10-15) .  The structures of synthesized compounds were confirmed by spectral and physical data. Some of the newly synthesized compounds exhibited antibacterial activity.

Keywords: schiff base , 1,8-naphthyridine , azetidine , organoselenium compounds , Vilsmeier-Haack.